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July 19, 2026PharmaceuticsOpen Access

Codonopsis pilosula Lipophilic Extract-Loaded Thermosensitive Nanogel Attenuates Skin Photoaging by Inhibiting the FGFR/PI3K/AKT/mTOR Pathway

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Authors

JZJ H ZhouYGYuhui GeRLR K Li

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Overview

Randomized trial demonstrates improved skin health in UV-exposed models using a plant-based nanogel, suggesting effective anti-aging treatment.

Key Points

  • This research aims to evaluate the effects of a Codonopsis pilosula nanogel on skin photoaging induced by UV radiation.
  • Developed a thermosensitive nanogel encapsulating CP-L-loaded transferosomes.
  • Assessed effects in a UV-induced photoaging mouse model and UVB-irradiated keratinocytes.
  • Conducted transcriptomic and molecular analyses to examine signaling pathway inhibition.
  • Topical application reduced wrinkling and epidermal thickness by 83.2% in mice (p < 0.01).
  • Cell viability increased from 53.0% to 89.4% in HaCaT cells (p < 0.01), while apoptosis decreased from 30.1% to 12.4% (p < 0.01).
  • Inhibited the FGFR/PI3K/AKT/mTOR pathway, reducing phosphorylation levels of key proteins by up to 57.3% (p < 0.01).

Cite This Study

Zhou et al. (2026) studied this question.

synapsesocial.com/papers/6a5c69c3118b92953e3ee035https://doi.org/10.3390/pharmaceutics18070869
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1A liposome–hydrogel composite ameliorates UVB-induced mouse skin photoaging through integrated antioxidant and extracellular matrix remodeling pathways2026
  2. 2A Nanoliposome Platform Co-Delivery of Hydroxypinacolone Retinoate and Carnosine for Enhanced Epidermal/Dermal Delivery and Multi-Functional Anti-Aging Efficacy2026 · 2 citations
  3. 3Lapagyl mitigates UV-induced inflammation and immunosuppression via Foxp3+ Tregs and CCL pathway: A single-cell transcriptomics study2024 · 8 citations
  4. 4Chlorella Polysaccharide Extract Attenuates Skin Aging via MAPK Pathway Suppression: Implications for Cosmetic Dermatology2026
  5. 5Codonopsis pilosula Polysaccharide (CPP) Alleviates D-Gal-Induced Aging and Gut Microbiota Dysbiosis2026