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July 19, 2026Langmuir

Sequence Patterning Governs Lipid-Selective Insertion and Membrane Perturbation of Antimicrobial Peptoids

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Authors

AOAdwoa Adubea OnomahKBKevin L. BickerMZMingfei Zhao

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Overview

Molecular dynamics reveals how antimicrobial peptoid sequences affect membrane insertion in varying lipid compositions, suggesting optimized designs for therapeutic applications.

Key Points

  • The research aims to understand how sequence patterns in antimicrobial peptoids influence their interactions with lipid membranes.
  • Conducted extensive all-atom molecular dynamics simulations of antimicrobial peptoid sequences.
  • Investigated model bacterial membranes with different lipid compositions.
  • Quantified insertion depth, residue-lipid contacts, and bilayer structural responses.
  • Deeper insertion correlated with increased anionic lipid content, affecting membrane thickness.
  • Alternating sequences provided uniform hydrophobic contacts, while diblock architectures induced localized perturbations.
  • Contact density was the most significant factor associated with insertion depth.

Cite This Study

Onomah et al. (2026) studied this question.

synapsesocial.com/papers/6a5c6a40118b92953e3ee51dhttps://doi.org/10.1021/acs.langmuir.6c01617
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