Key result
Among Japanese patients with atrial fibrillation, women experienced significantly less improvement in quality of life over 1 year compared with men (adjusted change in AFEQT score 5.89 vs 8.94; P=0.02).
Why the study?
Whether sex-related differences in AF extend to symptom burden, perceived QOL, or management patterns has been rarely studied, particularly in Asian countries.
Does female sex affect symptom burden, treatment strategy, and quality of life in Japanese patients with atrial fibrillation compared to male sex?
Cohort (n=1,534)
Yes
Does female sex affect symptom burden, treatment strategy, and quality of life in Japanese patients with atrial fibrillation compared to male sex?
Absolute Event Rate: 5.89% vs 8.94%
p-value: p=0.02
In Japanese patients with atrial fibrillation, women experience worse baseline quality of life and receive less rhythm control therapy than men, with the quality of life gap widening after one year of treatment.
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Ablation was associated with lower events in AF; leaves open causal benefit and sex-specific rhythm strategies.
Ikemura et al. (2019) conducted a cohort in Atrial Fibrillation (n=1,534). Female sex vs. Male sex was evaluated on Adjusted change in AFEQT overall summary score during 12 months (p=0.02). Among Japanese patients with atrial fibrillation, women experienced significantly less improvement in quality of life over 1 year compared with men (adjusted change in AFEQT score 5.89 vs 8.94; P=0.02).
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