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May 18, 2016JAMA CardiologyOpen Access

Differences in Clinical and Functional Outcomes of Atrial Fibrillation in Women and Men

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Why the study?

Do symptoms, quality of life, treatment, and outcomes differ between women and men with atrial fibrillation?

Population

10,135 patients with incident and prevalent atrial fibrillation enrolled at 176 sites in a nationwide…

Comparison

Female sex vs Male sex

Design

Cohort

Authors

JPJonathan P. PicciniDSDaJuanicia N. SimonBSBenjamin A. Steinberg

Discussion

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Overview

Women with AF show lower mortality yet higher embolic risk; leaves open whether sex-specific strategies improve outcomes.

Structured PICO

Do symptoms, quality of life, treatment, and outcomes differ between women and men with atrial fibrillation?

P
Population
10,135 patients with incident and prevalent atrial fibrillation enrolled at 176 sites in a nationwide outpatient registry (ORBIT-AF).
I
Intervention
Female sex
C
Comparator
Male sex
O
Outcome
Symptoms, quality of life (Atrial Fibrillation Effects on Quality of Life scores), AF treatment, cardiovascular outcomes, stroke or non-central nervous system embolism, and all-cause mortality

Women with atrial fibrillation have more symptoms and worse quality of life, and despite higher stroke risk, they have lower risk-adjusted all-cause and cardiovascular mortality compared to men.

Cite This Study

Piccini et al. (2016) studied this question.

synapsesocial.com/papers/6a7cda660594c5b5d191ae13https://doi.org/10.1001/jamacardio.2016.0529
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Also Consider

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  1. 1Prognosis and treatment of atrial fibrillation patients by European cardiologists: One Year Follow-up of the EURObservational Research Programme-Atrial Fibrillation General Registry Pilot Phase (EORP-AF Pilot registry)2014 · 240 citations
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  3. 3Comparisons of Characteristics and Outcomes Among Women and Men With Acute Myocardial Infarction Treated With Thrombolytic Therapy1996 · 258 citations
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  5. 5Refining Clinical Risk Stratification for Predicting Stroke and Thromboembolism in Atrial Fibrillation Using a Novel Risk Factor-Based Approach2009 · 6,816 citations