What does this research mean for the field?

Women with atrial fibrillation experience more symptoms than men but are significantly less likely to receive invasive rhythm control therapies such as electrical cardioversion or ablation. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

February 22, 2017HeartOpen Access

Gender differences in clinical presentation and 1-year outcomes in atrial fibrillation

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Why the study?

Does female gender affect clinical presentation, management, and 1-year outcomes in patients with atrial fibrillation?

Population

6,412 patients with atrial fibrillation from the PREvention oF thromboembolic events - European Registry in…

Comparison

Female gender vs Male gender

Design

Cohort

Follow-up

1 year

Authors

RSRenate B. SchnabelBroad Institute LPLadislav PecenCharles University FOFrancisco OjedaPreventive Cardiology

Discussion

Member takes

Implication

Sex differences in AF management and events persist in real-world data; leaves open optimal sex-specific strategies pending prospective validation.

Structured PICO

Does female gender affect clinical presentation, management, and 1-year outcomes in patients with atrial fibrillation?

Population

6,412 patients with atrial fibrillation from the PREvention oF thromboembolic events - European Registry in Atrial Fibrillation (PREFER in AF), 39.7% women.

Intervention

Female gender

Comparator

Male gender

Outcome

Gender differences in symptoms, risk factors, therapies and 1-year incidence of adverse outcomes (coronary revascularisation, acute coronary syndrome, heart failure, stroke/transient ischaemic attack/arterial thromboembolism, and major bleeding)hard clinical

In a real-world European registry, women with atrial fibrillation were more symptomatic but less likely to receive invasive rhythm control therapies, while experiencing lower 1-year odds of coronary events and heart failure compared to men.

Cite This Study

Schnabel et al. (2017) studied this question.

synapsesocial.com/papers/6a1998bf4b45427442ea734c https://doi.org/10.1136/heartjnl-2016-310406

Topics

Atrial fibrillation Persistent AF management Anticoagulation in AF AF ablation outcomes Women and heart disease

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Implication

Sex differences in AF management and events persist in real-world data; leaves open optimal sex-specific strategies pending prospective validation.

Gender differences in clinical presentation and 1-year outcomes in atrial fibrillation

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Topics

Gender differences in clinical presentation and 1-year outcomes in atrial fibrillation

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Topics

Also Consider