Comparison of Cardiovascular Risk Factors for Coronary Heart Disease and Stroke Type in Women
Key result
Cardiovascular risk factors like non-HDL cholesterol had stronger associations with CHD (HR 1.16; 95% CI 1.06-1.28) than with ischemic (HR 0.97) or hemorrhagic stroke (HR 0.76).
Why the study?
Do cardiovascular risk factors have differential effects on coronary heart disease, ischemic stroke, and hemorrhagic stroke in women?
Population
1731 women with incident cardiovascular disease during follow-up and a cohort of 1914 women from the…
Design
Cohort
Authors
Discussion
Loading...
Member takes
Implication
Differential effects on CVD subtypes in women may refine risk models; leaves open whether findings alter prevention strategies pending trials.
Study Design
Type
Cohort (n=3,645)
Structured PICO
Do cardiovascular risk factors have differential effects on coronary heart disease, ischemic stroke, and hemorrhagic stroke in women?
P
Population
3,645 women from the Women's Health Initiative Observational Study, including 1,731 with incident cardiovascular disease and a subcohort of 1,914 women, evaluated for 24 cardiovascular risk factors.
E
Exposure
Assessment of 24 cardiovascular risk factors (including apolipoproteins, hemoglobin A1c, high-sensitivity C-reactive protein, N-terminal pro-brain natriuretic peptide, and tissue plasminogen activator antigen)
O
Outcome
Coronary heart disease (myocardial infarction and CHD death), ischemic stroke, and hemorrhagic strokehard clinical
Main Result
Hazard Ratio: 1.16 (95% CI 1.06–1.28)
p-value: p=<0.05
Cardiovascular risk factors have similar effects on CHD and ischemic stroke in women, but differ substantially for hemorrhagic stroke, suggesting distinct biology and the need to separate ischemic and hemorrhagic outcomes in risk prediction.
Cite This Study
Leening et al. (2018) conducted a cohort in Cardiovascular disease (CHD and stroke) (n=3,645). Cardiovascular risk factors (e.g., non-HDL cholesterol) vs. Lower levels of risk factors was evaluated on Coronary heart disease (CHD) (HR 1.16, 95% CI 1.06-1.28, p=<0.05). Cardiovascular risk factors like non-HDL cholesterol had stronger associations with CHD (HR 1.16; 95% CI 1.06-1.28) than with ischemic (HR 0.97) or hemorrhagic stroke (HR 0.76).