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February 8, 2020Environment InternationalOpen Access

Phthalate exposure and neurodevelopment: A systematic review and meta-analysis of human epidemiological evidence

Elizabeth G. Radke Joseph M. Braun Rebecca Nachman Glinda S. Cooper

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Key Points

This review aims to identify neurodevelopmental effects associated with phthalate exposure based on epidemiological literature.
Conducted a systematic review of studies on phthalate exposure and neurodevelopmental outcomes in humans.
Included six phthalates: DEHP, DINP, DBP, DIBP, BBP, and DEP, with a random effects meta-analysis for cognition and motor effects in children ≤4 years old.
Evaluated studies for risk of bias and synthesized evidence on phthalate/outcome combinations.
Slight or indeterminate evidence of association for most phthalate/outcome combinations; moderate evidence for motor effects from BBP.
14 studies on cognition, 9 on motor effects, 20 on behavior including ADHD, and 7 on autism spectrum disorder included in the review.
No clear pattern of association identified overall, suggesting limitations in the epidemiological evidence.

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Implication

Systematic review identifies neurodevelopmental risks from phthalate exposure, highlighting implications for health.

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Cite This Study

Radke et al. (2020) studied this question.

synapsesocial.com/papers/6a5cc626bf1f0b8344004833 https://doi.org/10.1016/j.envint.2019.105408

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