Key result
Elevated plasma free fatty acids increased endothelial apoptosis by 4.2-fold compared with intra-individually matched low plasma FFA conditions (P<0.001).
Why the study?
Do free fatty acids trigger apoptosis and inhibit cell cycle progression in human vascular endothelial cells?
Do free fatty acids trigger apoptosis and inhibit cell cycle progression in human vascular endothelial cells?
Effect estimate: 4.2-fold increase
p-value: p=<0.001
Free fatty acid structure differentially affects endothelial cell proliferation and apoptosis, providing a potential mechanism for vascular dysfunction in insulin resistance.
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Elevated FFAs may promote endothelial injury in insulin resistance; leaves open causal role in human vascular disease.
Artwohl et al. (2003) studied Elevated plasma free fatty acids (n=10). Free fatty acids (FFAs) vs. Low plasma FFA conditions was evaluated on Endothelial apoptosis (4.2-fold increase, p=<0.001). Elevated plasma free fatty acids increased endothelial apoptosis by 4.2-fold compared with intra-individually matched low plasma FFA conditions (P<0.001).
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