Key result
Acute infusion of both long-chain and medium-chain triglycerides significantly reduced endothelium-dependent vasodilation compared to baseline (252% and 255% vs 436%; P<0.05).
Why the study?
Do free fatty acids impair endothelium-dependent vasodilation depending on their chain length or cyclooxygenase inhibition in normal volunteers?
Population
14 normal volunteers
Comparison
Infusion of long chain triglyceride emulsion and… vs Baseline conditions and intravenous ASA alone
Design
RCT, randomly allocated
Authors
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Small volunteer study leaves open whether FFA effects on endothelial function depend on chain length or PG production; larger trials needed.
RCT (n=14)
Randomly allocated
Do free fatty acids impair endothelium-dependent vasodilation depending on their chain length or cyclooxygenase inhibition in normal volunteers?
Absolute Event Rate: 252% vs 436%
p-value: p=<0.05
Free fatty acids impair endothelium-dependent vasodilation independently of their chain length and cyclooxygenase inhibition, which may contribute to the development of atherosclerotic cardiovascular disease.
Saula Vigili de Kreutzenberg (2000) conducted an RCT in Healthy volunteers (n=14). Long chain triglyceride (LCT) and medium chain triglyceride (MCT) emulsions vs. Baseline conditions was evaluated on Percent increase in forearm blood flow (FBF) during intraarterial acetylcholine (Ach) (p=<0.05). Acute infusion of both long-chain and medium-chain triglycerides significantly reduced endothelium-dependent vasodilation compared to baseline (252% and 255% vs 436%; P<0.05).
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