Why the study?
Does acute elevation of circulating free fatty acids impair endothelium-dependent vasodilation in lean healthy humans?
Population
Lean healthy humans, normal blood pressure, normal oral glucose tolerance test, not taking medications…
Comparison
Elevation of circulating free fatty acids via… vs Saline infusion (baseline conditions).
Follow-up
2 hours
Authors
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Supports FFA role in endothelial dysfunction; hypothesis-generating and does not yet inform practice.
Does acute elevation of circulating free fatty acids impair endothelium-dependent vasodilation in lean healthy humans?
Acute elevation of circulating free fatty acids impairs endothelium-dependent vasodilation, suggesting a mechanism for the endothelial dysfunction observed in insulin-resistant states.
Steinberg et al. (1997) studied this question.
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