Key result
A single dose of either losartan or perindopril completely prevented free fatty acid-induced endothelial dysfunction in healthy subjects.
Why the study?
Does inhibition of the renin-angiotensin system with a single dose of losartan or perindopril prevent free fatty acid-induced acute endothelial dysfunction in healthy subjects?
RCT (n=10)
Does inhibition of the renin-angiotensin system with a single dose of losartan or perindopril prevent free fatty acid-induced acute endothelial dysfunction in healthy subjects?
A single dose of losartan or perindopril completely prevents free fatty acid-induced acute endothelial dysfunction in healthy humans, suggesting a therapeutic rationale for RAS inhibition in patients with insulin resistance.
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ACEI/ARB may blunt acute FFA effects on endothelium; leaves open whether this improves long-term outcomes in insulin resistance.
Watanabe et al. (2005) conducted an RCT in Healthy subjects (n=10). Losartan or perindopril vs. Placebo was evaluated on Changes in forearm blood flow during intra-arterial infusion of acetylcholine. A single dose of either losartan or perindopril completely prevented free fatty acid-induced endothelial dysfunction in healthy subjects.
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