Key result
Intravenous infusion of both medium- and long-chain fatty acids did not influence endothelium-dependent vasodilation, whereas long-chain fatty acids alone reduced it by 20%.
Why the study?
Does an intravenous infusion of both medium-chain and long-chain fatty acids affect endothelium-dependent vasodilation differently than long-chain fatty acids alone in healthy volunteers?
Does an intravenous infusion of both medium-chain and long-chain fatty acids affect endothelium-dependent vasodilation differently than long-chain fatty acids alone in healthy volunteers?
Acute elevation of long-chain fatty acids impairs endothelium-dependent vasodilation, whereas a mixed elevation of medium- and long-chain fatty acids does not, suggesting fatty acid composition impacts endothelial function.
Answers are grounded in this paper and cite their sources.
Should not yet guide lipid emulsion selection in practice; leaves open whether fatty acid composition modulates endothelial function in vivo.
It has previously been shown that acute elevation of long-chain fatty acids (LCFA) impairs endothelium-dependent vasodilation (EDV) in humans. In this study, we tested the hypothesis that an elevation of both medium-chain fatty acids (MCFA) and LCFA affects the endothelium differently from LCFA elevation alone. Ten healthy volunteers received an intravenous infusion of Structolipid (structured TG, MCFA/LCFA ratio 1:1) and heparin for 2 h, while another 10 subjects received an infusion of Intralipid (LCFA only) and heparin. EDV and endothelium-independent vasodilation (EIDV) were studied in the forearm after local administration of methacholine chloride (2 and 4 microg/min) and sodium nitroprusside (5 and 10 microg/min). Forearm blood flow was determined by venous occlusion plethysmography. Intralipid and heparin increased circulating FA levels from 0.2 +/- 0.1 to 1.4 +/- 0.5 mmol/L (P < 0.001) and reduced EDV by 20% (P < 0.01). Although Structolipid and heparin increased circulating FA levels to a similar extent (from 0.4 +/- 0.1 to 1.8 +/- 0.4 mmol/L after 2 h), EDV was not significantly changed. EIDV increased slightly during both interventions (P < 0.05). In conclusion, an acute elevation of LCFA attenuated EDV, whereas an elevation of both MCFA and LCFA did not influence EDV. Thus, FA composition seems to be of importance for EDV in healthy humans.
No takes yet. Share an insight, caveat, or question.
Steer et al. (2003) studied Healthy volunteers (n=20). Structolipid (MCFA/LCFA ratio 1:1) and heparin vs. Intralipid (LCFA only) and heparin was evaluated on Endothelium-dependent vasodilation (EDV) (p=<0.01). Intravenous infusion of both medium- and long-chain fatty acids did not influence endothelium-dependent vasodilation, whereas long-chain fatty acids alone reduced it by 20%.
Synapse has enriched 10 related papers. Consider them for comparative context: