Key result
Preventing acute myocardial infarction may be achieved by increasing antioxidant and magnesium intake, adopting a low-carb diet, and limiting iron consumption.
Why the study?
Coronary atherosclerosis prevalence and resulting acute myocardial infarction fatalities are steadily rising, creating an imperative need for effective prevention strategies.
This review highlights the roles of oxidative stress, lipid metabolism, intermittent fasting, and micronutrients like magnesium and iron in the pathogenesis and prevention of acute myocardial infarction.
Supports oxidative stress targeting in atherosclerosis; extends evidence with first RCT data.
Cardiovascular disease stands as the leading cause of global mortality, with coronary atherosclerosis emerging as the prevailing pathological alteration within this condition. This lesion is distinguished by a notable escalation in oxidative stress. The prevalence of coronary atherosclerosis has exhibited a steady rise over time, leading to a consequential escalation in fatalities resulting from acute myocardial infarction caused by this condition. This alarming trend poses a significant threat to the well-being of our population. To address the imperative issue of preventing acute myocardial infarction caused by coronary atherosclerosis, this study offers a novel theoretical framework elucidating the pathogenesis and progression of acute myocardial infarction. By presenting and consolidating the findings of our research, this project aims to contribute to the prevention of acute myocardial infarction in recent years. The prevention of atherosclerotic plaque formation, narrowing of blood vessel lumen, obstruction, and myocardial ischemic infarction resulting from heightened oxidative stress in the human body, diminished vitamin C levels, impaired collagen formation, and unregulated cardiac wall repair system necessitates the reduction of oxidative intake, elimination of oxidative accumulation within the body, or augmentation of antioxidant intake. Furthermore, a substantial body of epidemiological evidence indicates that aberrant lipid metabolism serves as the primary predisposing factor for acute myocardial infarction. Additionally, both intermittent fasting and fat reduction therapy have demonstrated efficacy in preventing acute myocardial infarction. Moreover, it is worth noting that reducing non-high-density lipoprotein cholesterol (nHDL-C) is considered a secondary objective of fat reduction therapy. Moreover, magnesium is a significant dietary component that is frequently disregarded, yet numerous scientific investigations have substantiated the inverse relationship between the presence of magnesium ions in potable water and the prevalence of mortality due to coronary heart disease. However, iron, as an additional constituent, significantly contributes to the susceptibility of individuals to coronary artery disease and myocardial infarction.
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Qian Xu (2023) conducted a review in Coronary Atherosclerosis and Acute Myocardial Infarction. Dietary modifications (antioxidants, magnesium, low iron) was evaluated. Preventing acute myocardial infarction may be achieved by increasing antioxidant and magnesium intake, adopting a low-carb diet, and limiting iron consumption.
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