Socio-economic trajectories and cardiovascular disease mortality in older people: the English Longitudinal Study of Ageing
Key result
A stable low-social-class trajectory was associated with nearly double the risk of cardiovascular disease mortality compared with a stable high social class (HR 1.94; 95% CI 1.37-2.75).
Why the study?
Does a low life-course socio-economic trajectory increase cardiovascular disease mortality in older adults?
Population
7846 individuals (44% women) aged ≥ 50 years from the English Longitudinal Study of Ageing
Comparison
Stable low-social-class trajectory or lowest… vs Stable high social class across the life course…
Design
Cohort
Follow-up
8.4 years
Authors
Discussion
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Member takes
Implication
Life-course SES trajectories may influence older adults' CVD mortality; leaves open mediating roles of behavioral and inflammatory factors.
Study Design
Type
Cohort (n=7,846)
Structured PICO
Does a low life-course socio-economic trajectory increase cardiovascular disease mortality in older adults?
P
Population
7,846 individuals aged ≥ 50 years from the English Longitudinal Study of Ageing, followed for 8.4 years.
E
Exposure
Stable low-social-class trajectory or lowest life-course cumulative socio-economic status
C
Comparator
Stable high social class across the life course or highest life-course cumulative socio-economic status
O
Outcome
Cardiovascular disease mortalityhard clinical
Main Result
Hazard Ratio: 1.94 (95% CI 1.37–2.75)
Disadvantage across the life course is linked to increased cardiovascular mortality, partially explained by behavioral factors and inflammatory markers.
Limitations
- Alternative approaches such as counterfactual mediation modelling could not be applied
- Alternative approaches such as counterfactual mediation modelling could not be applied in this context
Cite This Study
Stringhini et al. (2017) conducted a cohort in Cardiovascular disease (n=7,846). Stable low-social-class trajectory vs. Stable high social class was evaluated on Cardiovascular disease mortality (HR 1.94, 95% CI 1.37-2.75). A stable low-social-class trajectory was associated with nearly double the risk of cardiovascular disease mortality compared with a stable high social class (HR 1.94; 95% CI 1.37-2.75).