Key result
The number of reported circulating vaccine-derived poliovirus outbreaks more than tripled from 9 to 29 between January 2018 and June 2019, with 86% caused by cVDPV2.
Why the study?
Genetically divergent vaccine-derived poliovirus strains can emerge during oral poliovirus vaccine use and cause outbreaks of paralytic poliomyelitis in underimmunized populations.
Population
Circulating vaccine-derived poliovirus outbreaks detected worldwide
Design
Surveillance report
Authors
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Sustained OPV use prevents wild poliovirus but risks cVDPV emergence; leaves open optimal strategies for complete eradication.
Observational
Yes
The number of circulating vaccine-derived poliovirus outbreaks has significantly increased, primarily driven by type 2 strains, highlighting the need for high population immunity and novel vaccines.
Jorba et al. (2019) conducted an observational in Vaccine-derived poliovirus outbreaks. Oral poliovirus vaccine (OPV) was evaluated on Number of reported cVDPV outbreaks. The number of reported circulating vaccine-derived poliovirus outbreaks more than tripled from 9 to 29 between January 2018 and June 2019, with 86% caused by cVDPV2.
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