Background: In 2011, three new direct-acting antivirals (DAAs) for HCV including sofosbuvir were accredited for HCVmanagement.Aim: To evaluate the impact of Sofosbuvir treatment on the histological structure of the lungs of adult male albino rat.Materials and Methods: 15 male rats were classified into: control group of 5 rats and sofosbuvir treated group of 10 rats thatreceived sofosbuvir orally in a dose of 4 mg/kg per day for 5 weeks. Blood samples were drawn to assess serum Transforminggrowth factor- β (TGF-β). Lung specimens were obtained for evaluation by light microscope. Alpha smooth Muscle Actin(α-SMA), E-cadherin immunohistochemistry, and statistical analysis were applied.Results: Marked increase in the mean value of serum TGF-β in Sofosbuvir treated group when compared to control group.Sofosbuvir resulted in histological and immunohistochemical changes in the lungs of sofosbuvir treated rats.Conclusion: Severe lung injury was detected after treatment with sofosbuvir. However further studies should be done todetermine the exact mechanism and more caution should be taken during administration of sofosbuvir.
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Hosny et al. (2020) studied this question.
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