Introduction: Metalaxyl is a widely used fungicide, with high residual level in crops that lead to dangerous human healthproblems.Aim of work: Study effect of metalaxyl on the thyroid gland structure& function and evaluate the efficacy of gingersupplementation.Materials and Methods: Thirty female albino rats were classified into three equal groups: Group I: (control group): Subdividedinto two equal subgroups 1a: given distilled water by gastric tube for 8 weeks. 1b: given ginger (100mg/kg/day) by gastric tubefor 8 weeks. Group II: given metalaxyl 3 times per week (130 mg/kg/day) by gastric tube for 8 weeks. Group III: given thesame dose of metalaxyl given to group II concomitant with ginger by gastric tube for 8 weeks. At end of the experiment, ratswere anaesthetized, and blood samples collected for measurement of T3, T4 and TSH. Thyroid gland biopsies were processedfor light and electron microscope examination. Immunohistochemical study was done for detection of PCNA. Results wereanalyzed morphometrically and statistically.Results: Metalaxyl-treated rats showed numerous interfollicular cells, vacuolated colloid, an increase height of follicularepithelium and many follicles exhibited stratification with vacuolated cytoplasm, dilatations of endoplasmic reticulum andirregular dark nuclei. Positive immunoreaction was detected in numerous nuclei of follicular cells of group II and significantdecrease in T3, T4 with highly increase in TSH. Group III showed a considerable degree of improvement of thyroid architecture.Conclusion: Metalaxyl affects the thyroid follicular structure and function. Concomitant administration of ginger was partiallyefficient in protecting it.
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Shaban et al. (2022) studied this question.
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