Key result
The abstract outlines a study evaluating the H2FPEF score in patients with HFpEF from the TOP-CAT trial, but does not report quantitative results.
Why the study?
The generalizability, prognostic utility, and clinical implications of the H2FPEF score in patients with established HFpEF were unknown.
Does the H2FPEF score have prognostic utility and interact with spironolactone treatment efficacy in patients with chronic stable HFpEF?
Cohort
Does the H2FPEF score have prognostic utility and interact with spironolactone treatment efficacy in patients with chronic stable HFpEF?
H2FPEF score evaluation in TOP-CAT HFpEF leaves prognostic utility and spironolactone interaction unquantified; further analyses required before clinical use.
risk factors Sources of Funding, see page 1853 T he heterogeneity in the diagnostic criteria for heart failure with preserved ejection fraction (HFpEF) is one of the key factors underlying the failure of several clinical trials of cardioprotective therapies in this patient population. 1Recently, Reddy et al 2 developed the H 2 FPEF score to estimate the diagnostic likelihood of HFpEF in clinical settings.However, the generalizability, prognostic utility, and clinical implications of the H 2 FPEF score in patients with established HFpEF is not known.Accordingly, we evaluated these questions regarding the H 2 FPEF score and sought to determine the presence of a sprinolactone-H 2 FPEF score treatment interaction among patients with chronic stable HFpEF enrolled in the TOP-CAT (Treatment of Preserved Cardiac Function Heart Failure with an Aldosterone Antagonist) trial.
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Segar et al. (2019) conducted a cohort in Heart failure with preserved ejection fraction (HFpEF). H2FPEF score was evaluated. The abstract outlines a study evaluating the H2FPEF score in patients with HFpEF from the TOP-CAT trial, but does not report quantitative results.
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