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Biofuel cells have been in the spotlight for the past century because of their potential and promise as a unique platform for sustainable energy harvesting from the human body and the environment. Because biofuel cells are typically developed in a small platform serving as a primary battery with limited fuel or as a rechargeable battery with repeated refueling, they have been interchangeably named biobatteries. Despite continuous advancements and creative proof-of-concept, however, the technique has been mired in its infancy for the past 100 years, which has provoked increasing doubts about its commercial viability. Low performance, instability, difficulties in operation, and unreliable and inconsistent power generation question the sustainable development of biofuel cells. However, the advancement in bioelectrocatalysis revolutionizes the electricity-producing capability of biofuel cells, promising an attractive, practical technique for specific applications. This perspective article will identify the misconceptions about biofuel cells that have led us in the wrong development direction and revisit their potential applications that can be realizable soon. Then, it will discuss the critical challenges that need to be immediately addressed for the commercialization of the selected applications. Finally, potential solutions will be provided. The article is intended to inspire the community so that fruitful commercial products can be developed soon.
Seokheun Choi (Wed,) studied this question.