Key result
Eccentric ergometer training in patients with severe COPD significantly increased isometric peak strength and relative thigh mass compared to concentric training, but did not induce fiber hypertrophy or mitochondrial adaptations.
Why the study?
Does eccentric ergometer training improve locomotor muscle strength and mitochondrial adaptation compared to concentric ergometer training in male patients with severe COPD?
Population
15 male patients with severe chronic obstructive pulmonary disease (COPD)
Comparison
Eccentric ergometer training (EET) for 10 weeks vs Conventional concentric ergometer training for…
Design
RCT, randomized
Follow-up
10 weeks
Authors
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EET may safely boost quadriceps strength in severe COPD at low ventilatory cost; leaves open mitochondrial benefits and need for RCTs before practice change.
RCT (n=15)
Randomized
No
Does eccentric ergometer training improve locomotor muscle strength and mitochondrial adaptation compared to concentric ergometer training in male patients with severe COPD?
p-value: p=<0.01
In patients with severe COPD, eccentric ergometer training improves muscle strength and mass but not mitochondrial adaptation, suggesting a potential role for sequential eccentric-concentric training.
MacMillan et al. (2017) conducted an RCT in Severe Chronic Obstructive Pulmonary Disease (COPD) (n=15). Eccentric Ergometer Training (EET) vs. Concentric Ergometer Training (CET) was evaluated on Isometric peak strength and relative thigh mass (p=<0.01). Eccentric ergometer training in patients with severe COPD significantly increased isometric peak strength and relative thigh mass compared to concentric training, but did not induce fiber hypertrophy or mitochondrial adaptations.
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