What question did this study set out to answer?

To compare the effects of 12 weeks of eccentric, concentric, and combined eccentric/concentric cycling training on muscle mass, functional capacity, cardiometabolic health, and quality of life in severe COPD patients, while characterizing muscle-fiber-specific molecular adaptations.

July 19, 2022BMC Pulmonary MedicineOpen Access

Effects of eccentric, concentric and eccentric/concentric training on muscle function and mass, functional performance, cardiometabolic health, quality of life and molecular adaptations of skeletal muscle in COPD patients: a multicentre randomised trial

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Authors

LPLuis PeñaililloUniversidad Andrés Bello DVDenisse Valladares-IdeUniversity of O'Higgins SJSebastián Jannas-VelasUniversity of O'Higgins

Discussion

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Implication

Randomized trial reports outcomes of eccentric, concentric, and combined cycling in severe COPD patients, highlighting tailored rehabilitation strategies to counter muscle wasting.

Key Points

To compare the effects of 12 weeks of eccentric, concentric, and combined eccentric/concentric cycling training on muscle mass, functional capacity, cardiometabolic health, and quality of life in severe COPD patients, while characterizing muscle-fiber-specific molecular adaptations.
A multicentre randomized trial (DRKS00027331) evaluating 12 weeks of concentric, eccentric, or combined eccentric/concentric cycling training in patients with severe COPD.
A nested subgroup analysis assessing molecular pathways of muscle protein synthesis, myogenesis, and degradation, along with fiber morphology, protein content, gene, and microRNA expression across isolated fiber types (I, IIa, and IIx).
Protocol publication; primary and secondary comparative effectiveness data between eccentric, concentric, and combined cycling training cohorts await trial completion.
Investigation is designed to establish whether combined eccentric and concentric cycling yields superior clinical improvements and determines the molecular mechanisms regulating muscle mass recovery in severe COPD.

Cite This Study

Peñailillo et al. (2022) studied this question.

synapsesocial.com/papers/6a026ec77adabae4d93729d3 https://doi.org/10.1186/s12890-022-02061-4

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Implication

Randomized trial reports outcomes of eccentric, concentric, and combined cycling in severe COPD patients, highlighting tailored rehabilitation strategies to counter muscle wasting.

Effects of eccentric, concentric and eccentric/concentric training on muscle function and mass, functional performance, cardiometabolic health, quality of life and molecular adaptations of skeletal muscle in COPD patients: a multicentre randomised trial

Discussion

Member takes

Implication

Key Points

Cite This Study

Effects of eccentric, concentric and eccentric/concentric training on muscle function and mass, functional performance, cardiometabolic health, quality of life and molecular adaptations of skeletal muscle in COPD patients: a multicentre randomised trial

Discussion

Member takes

Implication

Key Points

Cite This Study

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