Key result
Prasugrel was prescribed at discharge to 17% of patients undergoing percutaneous coronary intervention, with use increasing to 22.3% by late 2011 and 6-10% of users having known contraindications.
Why the study?
What are the contemporary patterns of prasugrel use and rates of inappropriate prescribing in patients undergoing percutaneous coronary intervention?
Population
55,821 patients who underwent percutaneous coronary intervention and were discharged alive from January 2010…
Comparison
Prasugrel prescription at hospital discharge vs Clopidogrel prescription at hospital discharge
Design
Cohort
Authors
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Inappropriate prasugrel prescribing was common despite contraindications; leaves open whether education or labeling changes improve real-world adherence.
Observational (n=55,821)
Yes
What are the contemporary patterns of prasugrel use and rates of inappropriate prescribing in patients undergoing percutaneous coronary intervention?
Absolute Event Rate: 17% vs 83%
Despite increasing use of prasugrel post-PCI, a significant proportion of patients receive it for off-label indications or despite known contraindications, highlighting a need for quality improvement.
Sandhu et al. (2013) conducted an observational in percutaneous coronary intervention (n=55,821). Prasugrel vs. Clopidogrel was evaluated on Prescription on hospital discharge. Prasugrel was prescribed at discharge to 17% of patients undergoing percutaneous coronary intervention, with use increasing to 22.3% by late 2011 and 6-10% of users having known contraindications.
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