Key result
Treatment with miR-21-5p alone recapitulated the procontractile effects of hMSC exosomes on human engineered cardiac tissue, likely via PI3K signaling.
Why the study?
Does miR-21-5p mediate the paracrine effects of hMSC exosomes on cardiac tissue contractility in human engineered cardiac tissue?
Population
Human engineered cardiac tissue (hECT) and human mesenchymal stem cells (hMSCs)
Comparison
miR-21-5p treatment or exosome-enriched fraction… vs Untreated controls, miR-scramble control, or…
Design
Preclinical
Authors
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miR-21-5p may enhance contractility via hMSC exosomes; leaves open whether it optimizes stem cell cardiotherapies.
Does miR-21-5p mediate the paracrine effects of hMSC exosomes on cardiac tissue contractility in human engineered cardiac tissue?
Exosomal miR-21-5p from human mesenchymal stem cells plays a key role in enhancing cardiac contractility and calcium handling, offering a potential target for optimizing stem cell-based cardiotherapies.
Mayourian et al. (2018) studied Heart disease. miR-21-5p vs. Untreated controls / miR-scramble control was evaluated on Cardiac tissue contractility and calcium handling gene expression. Treatment with miR-21-5p alone recapitulated the procontractile effects of hMSC exosomes on human engineered cardiac tissue, likely via PI3K signaling.
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