Key result
Exclusion of time-of-flight (TOF) correction in 82Rb PET/CT image reconstruction significantly decreased concordance in rest and stress myocardial blood flow quantification compared to standard TOF reconstruction.
Why the study?
Do changes in OSEM reconstruction parameters, specifically the exclusion of time-of-flight (TOF), affect the quantification of myocardial blood flow and flow reserve in 82Rb cardiac PET/CT?
Observational (n=20)
No
Do changes in OSEM reconstruction parameters, specifically the exclusion of time-of-flight (TOF), affect the quantification of myocardial blood flow and flow reserve in 82Rb cardiac PET/CT?
Effect estimate: ρc 0.769 (95% CI 0.678-0.861)
p-value: p=<0.05
In 82Rb cardiac PET/CT, the inclusion of time-of-flight (TOF) information is critical for accurate quantification of myocardial blood flow, whereas other OSEM reconstruction parameters have minimal impact.
Reconstruction parameters alter MBF/MFR estimates; leaves open optimal protocols before clinical standardization.
Background Our aim was to characterize the influence of time-of-flight (TOF) and point spread function (PSF) recovery corrections, as well as ordered subset expectation maximization (OSEM) reconstruction parameters, in 82Rb PET/CT quantification of myocardial blood flow (MBF) and myocardial flow reserve (MFR). Rest and stress list-mode dynamic 82Rb PET acquisition data from 10 patients without myocardial flow defects and 10 patients with myocardial blood flow defects were reconstructed retrospectively. OSEM reconstructions were performed with Gaussian filters of 4, 6, and 8 mm, different iterations, and subset numbers (2 × 24; 2 × 16; 3 × 16; 4 × 16). Rest and stress global, regional, and segmental MBF and MFR were computed from time activity curves with FlowQuant© software. Left ventricular segmentation using the 17-segment American Heart Association model was obtained. Results Whole left ventricle (LV) MBF at rest and stress were 0.97 ± 0.30 and 2.30 ± 1.00 mL/min/g, respectively, and MFR was 2.40 ± 1.13. Concordance was excellent and all reconstruction parameters had no significant impact on MBF, except for the exclusion of TOF which led to significantly decreased concordance in rest and stress MBF in patients with or without perfusion defects on a coronary artery basis and in MFR in patients with perfusion defects. Conclusions Changes in reconstruction parameters in perfusion 82Rb PET/CT studies influence quantitative MBF analysis. The inclusion of TOF information in the tomographic reconstructions had significant impact in MBF quantification.
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Chilra et al. (2017) conducted an observational in Coronary artery disease (suspected or known) (n=20). Exclusion of time-of-flight (TOF) correction in image reconstruction vs. Standard OSEM reconstruction with TOF was evaluated on Concordance of rest myocardial blood flow (MBF) compared to standard protocol (ρc 0.769, 95% CI 0.678-0.861, p=<0.05). Exclusion of time-of-flight (TOF) correction in 82Rb PET/CT image reconstruction significantly decreased concordance in rest and stress myocardial blood flow quantification compared to standard TOF reconstruction.
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