Key result
Sparfloxacin concentration-dependently lengthened the duration of action potential in rabbit Purkinje fibers, whereas levofloxacin and ofloxacin had no effect.
Why the study?
Do levofloxacin and ofloxacin alter cardiac repolarization compared to sparfloxacin in rabbit Purkinje fibers?
Population
Rabbit Purkinje fibers
Comparison
Levofloxacin and ofloxacin (1-100 microM) vs Sparfloxacin (1-100 microM)
Design
Preclinical
Authors
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Sparfloxacin prolongs repolarization in Purkinje fibers unlike levofloxacin or ofloxacin; leaves open differential clinical QT risk among fluoroquinolones.
Do levofloxacin and ofloxacin alter cardiac repolarization compared to sparfloxacin in rabbit Purkinje fibers?
Unlike sparfloxacin, levofloxacin and ofloxacin do not prolong cardiac repolarization in vitro, suggesting they lack the class III electrophysiological effects that can lead to QT prolongation and arrhythmias.
Mm et al. (1998) studied this question. Sparfloxacin vs. Levofloxacin and ofloxacin was evaluated on Cardiac action potential duration and repolarization. Sparfloxacin concentration-dependently lengthened the duration of action potential in rabbit Purkinje fibers, whereas levofloxacin and ofloxacin had no effect.
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