Key result
Calcific aortic stenosis management has evolved with new diagnostic imaging techniques and novel prosthetic valves, though pharmacotherapy has not yet been shown to slow disease progression.
Why the study?
Despite advances in research and prosthetic valve technologies, management of calcific aortic stenosis still involves unresolved complications.
This review summarizes the molecular mechanisms, hemodynamics, complications, diagnostics, and evolving treatments for calcific aortic stenosis.
Supports imaging- and valve-based management in practice; leaves open effective pharmacotherapy to alter progression.
Calcific aortic stenosis is a progressive disease that has become more prevalent in recent decades. Despite advances in research to uncover underlying biomechanisms, and development of new generations of prosthetic valves and replacement techniques, management of calcific aortic stenosis still comes with unresolved complications. In this review, we highlight underlying molecular mechanisms of acquired aortic stenosis calcification in relation to hemodynamics, complications related to the disease, diagnostic methods, and evolving treatment practices for calcific aortic stenosis.
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Zebhi et al. (2021) conducted a review in Calcific Aortic Stenosis. Calcific aortic stenosis management has evolved with new diagnostic imaging techniques and novel prosthetic valves, though pharmacotherapy has not yet been shown to slow disease progression.
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