What is the clinical evidence from this study?

Study design: Other. Intervention: Graded reductions in hindlimb perfusion via terminal aorta compression. Primary outcome: Cardiovascular responses (aortic pressure, heart rate, and ascending aortic flow).

What question did this study set out to answer?

The aim was to investigate how reduced hindlimb blood flow affects cardiovascular responses in exercising dogs.

September 1, 1983AJP Heart and Circulatory Physiology

Cardiovascular responses to graded reductions in hindlimb perfusion in exercising dogs

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Key result

Graded reductions in hindlimb perfusion during exercise in dogs caused initial bradycardia, followed by tachycardia and large increases in aortic pressure with further reductions.

Why the study?

How do graded reductions in hindlimb perfusion affect cardiovascular responses in exercising dogs?

Population

Six dogs trained to run at 2, 4, and 6 mph

Comparison

Graded reductions in hindlimb perfusion by… vs Different levels of perfusion and workloads

Design

Preclinical

Authors

CWC R WyssUnited States Department of Veterans Affairs JAJeffrey L. ArdellElectrophysiology ASA. M. ScherUniversity of Washington

Discussion

Member takes

Implication

Graded hindlimb hypoperfusion elicits biphasic responses in exercising dogs; hypothesis-generating for muscle afferent roles in human exercise hemodynamics.

Key Points

The aim was to investigate how reduced hindlimb blood flow affects cardiovascular responses in exercising dogs.
Six dogs trained to run at 2, 4, and 6 mph were subjected to compression of the terminal aorta to induce graded reductions in hindlimb perfusion.
Cardiovascular parameters including aortic pressure, heart rate, and ascending aortic flow were measured in response to alterations in terminal aortic flow and femoral arterial pressure.
Small reductions in terminal aortic flow and femoral arterial pressure caused bradycardia, small decreases in cardiac output, and small increases in aortic pressure.
Further reductions led to tachycardia, increased cardiac output, and large increases in aortic pressure, with a noted increase of 1 mmHg in aortic pressure for each 1-mmHg fall in femoral arterial pressure.
The degree of cardiovascular response varied with exercise intensity, with smaller reductions in perfusion needed for significant responses at higher speeds.

Structured PICO

How do graded reductions in hindlimb perfusion affect cardiovascular responses in exercising dogs?

Population

6 dogs trained to run at 2, 4, and 6 mph subjected to graded reductions in hindlimb perfusion.

Intervention

Graded reductions in hindlimb perfusion by compressing the terminal aorta

Comparator

Different levels of perfusion and workloads

Outcome

Cardiovascular responses including aortic pressure (AP), heart rate, and ascending aortic flow (CO)surrogate

Metabolic feedback from muscle may play a role in cardiovascular responses to exercise at moderate-to-high workloads or when muscle perfusion is restricted.

Cite This Study

Wyss et al. (1983) studied this question. Graded reductions in hindlimb perfusion via terminal aorta compression was evaluated on Cardiovascular responses (aortic pressure, heart rate, and ascending aortic flow). Graded reductions in hindlimb perfusion during exercise in dogs caused initial bradycardia, followed by tachycardia and large increases in aortic pressure with further reductions.

synapsesocial.com/papers/6a5d7e33a170fefb8e8a40e7 https://doi.org/10.1152/ajpheart.1983.245.3.h481

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Implication

Graded hindlimb hypoperfusion elicits biphasic responses in exercising dogs; hypothesis-generating for muscle afferent roles in human exercise hemodynamics.

Cardiovascular responses to graded reductions in hindlimb perfusion in exercising dogs

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Cardiovascular responses to graded reductions in hindlimb perfusion in exercising dogs

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

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