Key result
Bilateral femoral artery ligation in rats significantly augmented mean arterial pressure and heart rate responses to treadmill running compared to baseline (P<0.05 for both sexes).
Why the study?
Does bilateral femoral artery ligation cause exaggerated cardiovascular responses to dynamic exercise in rats?
Population
10 Sprague-Dawley rats (5 male, 5 female)
Comparison
Bilateral femoral artery ligation vs Before ligation (baseline)
Design
Preclinical
Follow-up
up to 65 days postligation
Authors
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Hypothesis-generating for exaggerated exercise pressor reflexes in PAD; leaves open translation to human cardiovascular responses.
Does bilateral femoral artery ligation cause exaggerated cardiovascular responses to dynamic exercise in rats?
p-value: p=< 0.05
A chronic deficit in muscle blood flow capacity from femoral artery obstruction in rats causes persistent, exaggerated pressor and cardioaccelerator responses to exercise, modeling peripheral artery disease.
Kuczmarski et al. (2017) studied Peripheral arterial insufficiency (n=10). Bilateral femoral artery ligation vs. Before ligation (baseline) was evaluated on Change in mean arterial pressure (MAP) and heart rate (HR) during treadmill running (p=< 0.05). Bilateral femoral artery ligation in rats significantly augmented mean arterial pressure and heart rate responses to treadmill running compared to baseline (P<0.05 for both sexes).
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