What is the clinical evidence from this study?

Study design: Other. Intervention: Voluntary exercise vs. Treadmill exercise (30 m/min for 30 s). Primary outcome: Cardiovascular responses including mean arterial pressure (MAP), heart rate (HR), mesenteric blood flow (BFmes), and iliac blood flow.

What does this research mean for the field?

Voluntary exercise produces significantly smaller increases in mean arterial pressure and heart rate and less mesenteric vasoconstriction compared to treadmill exercise at similar speeds in rats. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

To compare the acute arterial pressure, heart rate, and regional vascular blood flow adjustments between voluntary wheel running and forced treadmill exercise in rats.

September 1, 1993Journal of Applied Physiology

Cardiovascular responses to voluntary and treadmill exercise in rats

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Key result

Voluntary exercise yields ~67% smaller MAP increases and blunts HR elevations versus treadmills in rats.

n=12

Why the study?

Does voluntary exercise compared to treadmill exercise produce different cardiovascular responses in rats?

Population

Male Sprague-Dawley rats (n = 12) instrumented with Doppler flow probes and a carotid catheter

Comparison

Voluntary exercise vs Treadmill exercise (30 s at 30 m/min)

Design

Preclinical

Authors

SYSusan L. YanceyUniversity of Louisville JOJ. M. OvertonFlorida State University

Discussion

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Implication

Rat data indicate blunted pressor responses during voluntary versus forced exercise; leaves open translation to human cardiovascular physiology.

Key Points

To compare the acute arterial pressure, heart rate, and regional vascular blood flow adjustments between voluntary wheel running and forced treadmill exercise in rats.
Instrumented male Sprague-Dawley rats (n = 12) with Doppler flow probes and carotid catheters after 2 weeks of wheel and treadmill familiarization.
Measured mean arterial pressure (MAP), heart rate (HR), mesenteric blood flow, and iliac blood flow during matched bouts of voluntary running (33 ± 2 m/min for 26 ± 5 s) and treadmill running (30 m/min for 30 s).
Treadmill exercise elicited significantly higher increases in MAP (21 ± 5 mmHg vs. 7 ± 3 mmHg) and HR (95 ± 9 beats/min vs. 63 ± 7 beats/min) compared with voluntary exercise.
Mesenteric blood flow decreased significantly more during treadmill running (57 ± 4%) than voluntary running (32 ± 6%), whereas iliac blood flow increases were 169 ± 31% and 112 ± 15%, respectively.

Structured PICO

Does voluntary exercise compared to treadmill exercise produce different cardiovascular responses in rats?

Population

12 male Sprague-Dawley rats instrumented to measure cardiovascular responses during voluntary and treadmill exercise.

Intervention

Voluntary exercise (speed = 33 +/- 2 m/min, duration = 26 +/- 5 s)

Comparator

Treadmill exercise (30 s at 30 m/min)

Outcome

Mean arterial pressure (MAP), heart rate (HR), mesenteric blood flow (BFmes), and iliac blood flowsurrogate

Voluntary exercise in rats elicits similar patterns of cardiovascular adjustments as treadmill exercise, but with significantly smaller magnitudes of change in MAP, HR, and mesenteric blood flow.

Cite This Study

Yancey et al. (1993) studied this question. Voluntary exercise vs. Treadmill exercise (30 m/min for 30 s) was evaluated on Cardiovascular responses including mean arterial pressure (MAP), heart rate (HR), mesenteric blood flow (BFmes), and iliac blood flow. Voluntary exercise produced significantly smaller increases in mean arterial pressure (7 vs 21 mmHg) and heart rate (63 vs 95 beats/min) compared to treadmill exercise in rats.

synapsesocial.com/papers/6aa7beedbfbaf8fff057446b https://doi.org/10.1152/jappl.1993.75.3.1334

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Implication

Rat data indicate blunted pressor responses during voluntary versus forced exercise; leaves open translation to human cardiovascular physiology.

Cardiovascular responses to voluntary and treadmill exercise in rats

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Cardiovascular responses to voluntary and treadmill exercise in rats

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Also Consider

Also Consider