Key result
Voluntary exercise in rats significantly increased the dose of aconitine required to provoke ventricular arrhythmias compared to sedentary controls (489 and 505 vs 173 μg; P<0.05).
Why the study?
Does voluntary exercise improve resistance to cardiac arrhythmias in rats?
Population
Rats (n=22)
Comparison
Voluntary exercise for 6 weeks vs Sedentary controls
Design
Preclinical
Follow-up
7 weeks (6 weeks exercise protocol followed by 1 week rest)
Authors
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Supports exercise-mediated arrhythmia resistance in rat models; leaves open human translation pending clinical trials.
Does voluntary exercise improve resistance to cardiac arrhythmias in rats?
Absolute Event Rate: 489% vs 173%
p-value: p=<0.05
Long-term voluntary exercise in rats provides enduring cardioprotective effects, significantly increasing resistance to aconitine-induced ventricular arrhythmias.
Beig et al. (2010) studied this question. Voluntary exercise vs. Sedentary controls was evaluated on Dose of aconitine required to provoke ventricular arrhythmias (p=<0.05). Voluntary exercise in rats significantly increased the dose of aconitine required to provoke ventricular arrhythmias compared to sedentary controls (489 and 505 vs 173 μg; P<0.05).
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