Key result
Magnetic resonance imaging reliably detected a continuous improvement in the left ventricular outflow tract area after septal artery embolization, which correlated with symptom amelioration (r2=0.86).
Why the study?
Does magnetic resonance imaging reliably quantify left ventricular outflow tract obstruction and correlate with symptom improvement in patients with hypertrophic obstructive cardiomyopathy after septal artery embolization?
Observational (n=10)
Does magnetic resonance imaging reliably quantify left ventricular outflow tract obstruction and correlate with symptom improvement in patients with hypertrophic obstructive cardiomyopathy after septal artery embolization?
Effect estimate: r2=0.86
MRI is a reliable noninvasive modality for quantifying left ventricular outflow tract obstruction and correlates strongly with symptom improvement after septal artery embolization in HOCM.
Supports MRI monitoring of LVOT response after embolization; leaves open prospective validation before routine adoption.
BACKGROUND: We tested the value of magnetic resonance imaging (MRI) in the follow-up of patients with hypertrophic obstructive cardiomyopathy after septal artery embolization. MRI provides a noninvasive visualization of transplanar turbulent flow in order to quantify left ventricular outflow tract obstruction. METHODS AND RESULTS: We followed 10 patients who were treated with septal artery embolization for 12 months. We used gradient echo sequences to document continuous improvement of the outflow tract area and T1- and T2-weighted spin echo sequences to visualize myocardial infarction. A continuous, but not linear, improvement of the outflow tract area occurred after septal artery embolization during the 12-month follow-up period. The improvement of the outflow tract area correlated well with the amelioration of symptoms (r(2)=0.86). CONCLUSIONS: We conclude that MRI reliably detects the degree of obstruction in patients with hypertrophic obstructive cardiomyopathy. This modality may be especially useful for follow-up after septal artery embolization.
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Schulz‐Menger et al. (2000) conducted an observational in Hypertrophic obstructive cardiomyopathy (n=10). Magnetic resonance imaging (MRI) was evaluated on Correlation between improvement of the outflow tract area and amelioration of symptoms (r2=0.86). Magnetic resonance imaging reliably detected a continuous improvement in the left ventricular outflow tract area after septal artery embolization, which correlated with symptom amelioration (r2=0.86).
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