Key result
HeartLogic linked to ~50% fewer worsening HF events vs standard care alone.
Why the study?
HeartLogic is safe to integrate into clinical practice, but whether it provides clinical benefit on top of standard care and device telemonitoring in patients with HF remained unknown.
Does the HeartLogic algorithm reduce worsening heart failure events when added to standard care in patients with heart failure and an ICD?
Cohort (n=254)
Open-label
Yes
Does the HeartLogic algorithm reduce worsening heart failure events when added to standard care in patients with heart failure and an ICD?
Absolute Event Rate: 1% vs 2%
p-value: p=0.004
Integrating the ICD-based HeartLogic algorithm into standard care for patients with heart failure is associated with significantly fewer worsening heart failure events and shorter hospital stays.
May reduce worsening HF events in ICD patients; hypothesis-generating pending randomized confirmation.
BACKGROUND: The implantable cardiac defibrillator-based HeartLogic algorithm aims to detect impending fluid retention in patients with heart failure (HF). Studies show that HeartLogic is safe to integrate into clinical practice. The current study investigates whether HeartLogic provides clinical benefit on top of standard care and device telemonitoring in patients with HF. METHODS: A multicenter, retrospective, propensity-matched cohort analysis was performed in patients with HF and implantable cardiac defibrillators, and it compared HeartLogic to conventional telemonitoring. The primary endpoint was the number of worsening HF events. Hospitalizations and ambulatory visits due to HF were also evaluated. RESULTS: Propensity score matching yielded 127 pairs (median age 68 years, 80% male). Worsening HF events occurred more frequently in the control group (2; IQR 0-4) compared to the HeartLogic group (1; IQR 0-3; P = 0.004). The number of HF hospitalization days was higher in controls than in the HeartLogic group (8; IQR 5-12 vs 5; IQR 2-7; P = 0.023), and ambulatory visits for diuretic escalation were more frequent in the control group than in the HeartLogic group (2; IQR 0-3 vs 1; IQR 0-2; P = 0.0001). CONCLUSION: Integrating the HeartLogic algorithm in a well-equipped HF care path on top of standard care is associated with fewer worsening HF events and shorter duration of fluid retention-related hospitalizations.
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Feijen et al. (2023) conducted a cohort in Heart failure with implantable cardiac defibrillator (n=254). HeartLogic algorithm vs. Standard care (conventional telemonitoring) was evaluated on Number of worsening heart failure events (p=0.004). The HeartLogic algorithm on top of standard care was associated with a significant reduction in the median number of worsening heart failure events compared to standard care alone.
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