Key result
Elevated plasma levels of TNF-alpha, IL-6, and IL-10 in patients with stable CAD and preserved LVEF significantly correlated with indices of LV diastolic dysfunction (all P<0.001).
Why the study?
Are plasma levels of inflammatory cytokines (TNF-alpha, IL-6, IL-10) associated with left ventricular diastolic dysfunction in patients with stable CAD and preserved systolic function?
Population
223 participants, including 126 patients with single vessel stable coronary artery disease, 58 patients with…
Design
Cross-sectional
Authors
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Inflammatory markers associate with diastolic dysfunction in stable CAD; leaves open causal role or therapeutic targeting.
Cross-Sectional (n=223)
Are plasma levels of inflammatory cytokines (TNF-alpha, IL-6, IL-10) associated with left ventricular diastolic dysfunction in patients with stable CAD and preserved systolic function?
p-value: p=<0.001
In patients with stable CAD and preserved LVEF, elevated plasma levels of inflammatory cytokines (TNF-alpha and IL-6) are significantly associated with echocardiographic indices of left ventricular diastolic dysfunction.
Kosmala et al. (2008) conducted a cross-sectional in Stable angina pectoris and preserved left ventricular systolic performance (n=223). Plasma levels of TNF-alpha, IL-6, and IL-10 vs. Healthy controls was evaluated on Relationship between plasma cytokine levels and LV diastolic function indices (p=<0.001). Elevated plasma levels of TNF-alpha, IL-6, and IL-10 in patients with stable CAD and preserved LVEF significantly correlated with indices of LV diastolic dysfunction (all P<0.001).
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