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Inflammatory Mediators and Cell Adhesion Molecules as Indicators of Severity of Atherosclerosis

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This research aims to understand how inflammatory mediators and cell adhesion molecules relate to the severity of atherosclerosis.
Assessed CRP levels in a random sample of 1317 participants from the Rotterdam Study.
Studied IL-6 and soluble cell adhesion molecules in a subsample of 714 participants using multivariate analyses.
Measured atherosclerosis severity via the ankle-arm index and carotid intima-media thickness.
CRP showed an inverse association with the ankle-arm index (beta=-0.023, 95% CI -0.033 to -0.012).
CRP levels were associated with carotid intima-media thickness (beta=0.018, 95% CI 0.010 to 0.027).
Highest tertile of CRP indicated increased odds of moderate to severe carotid plaques (OR=2.0, 95% CI 1.3 to 3.0).

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Randomized trial investigates inflammatory indicators of atherosclerosis severity in a population, suggesting important associations.

Meer et al. (2002) studied this question.

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