Key result
Higher CRP linked to subclinical femoral atherosclerosis and Ox-LDL antibodies in healthy men.
Why the study?
High serum C-reactive protein levels have been linked to atherosclerotic disease and its complications, but their relationship with subclinical atherosclerosis and antibodies to oxidized LDL in healthy men needed investigation.
Are serum CRP levels associated with subclinical atherosclerosis and antibodies to oxidized LDL in healthy men?
Observational (n=391)
Are serum CRP levels associated with subclinical atherosclerosis and antibodies to oxidized LDL in healthy men?
Effect estimate: r = 0.14
p-value: p=0.010
In healthy 58-year-old men, elevated CRP levels are associated with femoral artery atherosclerosis and oxidized LDL antibodies, though the atherosclerosis association is not independent of traditional risk factors.
No takes yet. Share an insight, caveat, or question.
CRP links to femoral atherosclerosis may reflect confounding by smoking/LDL; leaves open independent inflammatory role in subclinical disease.
Hulthe et al. (2001) conducted an observational in Clinically healthy (n=391). C-reactive protein (CRP) levels was evaluated on ultrasound-assessed subclinical atherosclerosis in the femoral artery (r = 0.14, p=0.010). In healthy 58-year-old men, CRP levels were associated with subclinical atherosclerosis in the femoral artery (r=0.14, P=0.010) and antibody titres to Ox-LDL (r=0.19, P<0.001).
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