Associations of C-Reactive Protein With Measures of Obesity, Insulin Resistance, and Subclinical Atherosclerosis in Healthy, Middle-Aged Women
Key result
Body mass index was strongly associated with C-reactive protein in healthy, middle-aged women, explaining 29.7% of its variance and accounting for its link to insulin resistance variables.
Why the study?
Is C-reactive protein associated with measures of obesity, insulin resistance, and subclinical atherosclerosis in healthy, middle-aged women?
Population
186 healthy, middle-aged women selected from the general population
Design
Cross-sectional
Authors
Discussion
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Implication
BMI strongly drives CRP in healthy women; supports adiposity-inflammation link but leaves causal role in insulin resistance open.
Key Points
- To assess the relationship of C-reactive protein with measures of obesity, variables of insulin resistance syndrome, and carotid artery intima-media thickness in healthy, middle-aged women.
- Assessed a population-based sample of 186 healthy, middle-aged women.
- Measured plasma C-reactive protein, body mass index, waist circumference, metabolic variables, and common carotid artery intima-media thickness.
- Evaluated relationships using regression analyses with and without adjustment for body mass index.
- C-reactive protein was strongly associated with body mass index and waist circumference, with body mass index explaining 29.7% of the variance in C-reactive protein compared to only 3.7% explained by carotid intima-media thickness.
- Associations between C-reactive protein and insulin resistance variables (blood pressure, insulin, lipids, tissue-type plasminogen activator) disappeared after controlling for body mass index, remaining significant only for plasminogen activator inhibitor-1 antigen.
- The association of C-reactive protein with common carotid artery intima-media thickness was weak and limited specifically to ever-smokers.
Study Design
Type
Cross-Sectional (n=186)
Structured PICO
Is C-reactive protein associated with measures of obesity, insulin resistance, and subclinical atherosclerosis in healthy, middle-aged women?
P
Population
186 healthy, middle-aged women selected from the general population
O
Outcome
Relationship of C-reactive protein (CRP) with measures of obesity, variables of the insulin resistance syndrome, and intima-media thickness of the common carotid arteriessurrogate
Adiposity is strongly associated with CRP in healthy, middle-aged women, and BMI accounts for the relationship between CRP and other variables of the insulin resistance syndrome.
Cite This Study
Hak et al. (1999) conducted a cross-sectional in Healthy (n=186). C-reactive protein (exposure) was evaluated on Relationship of C-reactive protein with measures of obesity, insulin resistance syndrome, and common carotid artery intima-media thickness. Body mass index was strongly associated with C-reactive protein in healthy, middle-aged women, explaining 29.7% of its variance and accounting for its link to insulin resistance variables.