Key result
Baseline mid septal myocardial work efficiency ≤42% combined with mid lateral myocardial work index ≥740 mmHg% predicted CRT response with 79% sensitivity and 82% specificity (AUC=0.830, P<0.001).
Why the study?
Non-invasive LV pressure-strain loops provide myocardial work indices overcoming load-dependence, but their role in predicting CRT response needed evaluation.
Do non-invasive myocardial work indices derived from left ventricular pressure-strain loops predict response to cardiac resynchronization therapy in heart failure patients?
Population
106 HF patients scheduled for CRT
Comparison
Baseline and 6-month global and segmental myocardial work indices in CRT responders vs non-responders
Design
Prospective observational cohort study
Follow-up
6 months
Authors
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Segmental myocardial work indices may refine CRT candidate selection in heart failure; this Level 3 finding leaves open the need for prospective validation.
Observational (n=106)
Do non-invasive myocardial work indices derived from left ventricular pressure-strain loops predict response to cardiac resynchronization therapy in heart failure patients?
Odds Ratio: 1.003 (95% CI 1.002–1.004)
p-value: p=<0.001
Non-invasive myocardial work indices, specifically mid septal myocardial work efficiency and mid lateral myocardial work index, can independently predict response to cardiac resynchronization therapy.
Zhu et al. (2021) conducted an observational in Heart failure (n=106). Non-invasive myocardial work indices (mid septal MWE and mid lateral MWI) was evaluated on Response to CRT (≥15% reduction in LV end-systolic volume and ≥1 NYHA functional class improvement at 6-month follow-up) (OR 1.003, 95% CI 1.002-1.004, p=<0.001). Baseline mid septal myocardial work efficiency ≤42% combined with mid lateral myocardial work index ≥740 mmHg% predicted CRT response with 79% sensitivity and 82% specificity (AUC=0.830, P<0.001).
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