Role of myocardial constructive work in the identification of responders to CRT
Why the study?
Does baseline global myocardial constructive work (CWtot) predict echocardiographic response to cardiac resynchronization therapy in patients with symptomatic heart failure?
Structured PICO
Does baseline global myocardial constructive work (CWtot) predict echocardiographic response to cardiac resynchronization therapy in patients with symptomatic heart failure?
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Population
97 patients with symptomatic heart failure (ejection fraction: 27 ± 6%, QRS duration 164 ± 18 ms) undergoing cardiac resynchronization therapy (CRT) implantation
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Intervention
Baseline assessment of global myocardial constructive work (CWtot) via pressure-strain loops (PSLs) using 2D and speckle tracking echocardiography prior to CRT
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Outcome
CRT-positive response (CRT-PR), defined as > 15% reduction in left ventricular (LV) end-systolic volume at 6-month follow-upsurrogate
Global myocardial constructive work > 1057 mmHg% assessed by pressure-strain loops is a strong independent predictor of positive echocardiographic response to CRT in patients with symptomatic heart failure.
Authors
Discussion
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Implication
May aid CRT response prediction in symptomatic HF; hypothesis-generating pending prospective validation.
Cite This Study
Galli et al. (2017) studied this question.