Key result
A cardiac 123I MIBG washout rate ≥27% was associated with significantly higher mortality (35.1% vs 0%, p=0.001) and morbidity (p<0.001) compared to a rate <27% in chronic heart failure patients.
Why the study?
Does cardiac 123I MIBG washout rate predict mortality and morbidity in patients with chronic heart failure and LVEF < 40%?
Population
79 patients with chronic heart failure and left ventricular ejection fraction < 40% treated at a tertiary…
Comparison
Cardiac iodine-123 metaiodobenzylguanidine… vs Cardiac 123I MIBG imaging with a washout rate <…
Design
Cohort
Follow-up
1 to 52 months
Authors
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May enhance risk stratification in chronic HF; leaves open prospective validation before clinical adoption.
Cohort (n=79)
No
Does cardiac 123I MIBG washout rate predict mortality and morbidity in patients with chronic heart failure and LVEF < 40%?
Absolute Event Rate: 35.1% vs 0%
p-value: p = 0.001 and p < 0.001
An accelerated cardiac 123I MIBG washout rate (≥ 27%) is a strong predictor of increased mortality and heart failure hospitalization in patients with chronic HFrEF.
Ogita et al. (2001) conducted a cohort in chronic heart failure (n=79). Cardiac 123I MIBG washout rate ≥27% vs. Cardiac 123I MIBG washout rate <27% was evaluated on Mortality and morbidity (p=p = 0.001 and p < 0.001). A cardiac 123I MIBG washout rate ≥27% was associated with significantly higher mortality (35.1% vs 0%, p=0.001) and morbidity (p<0.001) compared to a rate <27% in chronic heart failure patients.
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