Key result
The rs2200733 T allele was significantly associated with atrial fibrillation and atrial flutter in an Italian population (OR 2.17; P<0.001).
Why the study?
Is the rs2200733 T allele associated with atrial fibrillation and atrial flutter in an Italian population?
Case-Control (n=426)
Is the rs2200733 T allele associated with atrial fibrillation and atrial flutter in an Italian population?
Odds Ratio: 2.17
p-value: p=<0.001
The rs2200733 T allele is significantly associated with an increased risk of atrial fibrillation and atrial flutter in the Italian population, confirming previous findings.
Confirms rs2200733-AF/AFL link in Italians; extends Icelandic data to additional European ancestry without changing practice.
BACKGROUND: Atrial fibrillation (AF) and atrial flutter (AFL) are common cardiac conduction disorders affecting many people. Recent studies on sporadic cases of AF/AFL showed a significant association of the single nucleotide polymorphism rs2200733T with the disease, suggesting a genetic factor in the development of the disease. OBJECTIVES: To determine the association of rs2200733 with AF/AFL derived from an Italian population sample. SUBJECTS: 78 patients with AF/AFL and 348 controls took part in the study. DESIGN: Genetic case-control study. RESULTS: The results indicate that there is a positive, significant association between the rs2200733 T allele and patients with AF/AFL of Italian origin (allelic p<0.001 with OR = 2.17). CONCLUSION: These results derived from a sample of the Italian population agree with previously reported findings from an Icelandic study, which also found that the minor allele rs2200733 was associated with AF/AFL disease.
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Anselmi et al. (2008) conducted a case-control in Atrial fibrillation and atrial flutter (n=426). rs2200733 T allele vs. Controls without the disease was evaluated on Association with atrial fibrillation and atrial flutter (OR 2.17, p=<0.001). The rs2200733 T allele was significantly associated with atrial fibrillation and atrial flutter in an Italian population (OR 2.17; P<0.001).
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