Calsarcins, a novel family of sarcomeric calcineurin-binding proteins
Key result
A two-hybrid screen identified calsarcins, a novel family of sarcomeric proteins that tether calcineurin to alpha-actinin at the z-line of cardiac and skeletal muscle cells.
Population
Preclinical model (cardiac and skeletal muscle cells/embryogenesis)
Design
Preclinical
Authors
Discussion
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Member takes
Implication
Hypothesis-generating for sarcomeric calcineurin signaling; leaves open any role in human cardiac disease.
Structured PICO
P
Population
Preclinical model (cardiac and skeletal muscle cells/embryogenesis)
E
Exposure
Two-hybrid screen using calcineurin catalytic subunit
O
Outcome
Identification of cardiac calcineurin-interacting proteins
Identifies calsarcins as a novel family of sarcomeric proteins that link calcineurin with the contractile apparatus, potentially coupling muscle activity to calcineurin activation.
Cite This Study
Frey et al. (2000) studied this question. A two-hybrid screen identified calsarcins, a novel family of sarcomeric proteins that tether calcineurin to alpha-actinin at the z-line of cardiac and skeletal muscle cells.