Calsarcin-3, a Novel Skeletal Muscle-specific Member of the Calsarcin Family, Interacts with Multiple Z-disc Proteins
Key result
Calsarcin-3 is a novel skeletal muscle-specific protein enriched in fast-twitch fibers that interacts with calcineurin and multiple Z-disc proteins.
Population
Skeletal muscle (specifically fast-twitch muscle fibers)
Design
Preclinical
Authors
Discussion
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Member takes
Implication
Calsarcin-3 defines a fast-twitch Z-disc interactome; leaves open its role in human myopathies or calcineurin signaling.
Structured PICO
P
Population
Skeletal muscle (specifically fast-twitch muscle fibers)
I
Intervention
Characterization of calsarcin-3
O
Outcome
Protein interactions (calcineurin, alpha-actinin, gamma-filamin, telethonin, ZASP/Cypher/Oracle)
Calsarcin-3 is a novel skeletal muscle-specific protein that interacts with calcineurin and Z-disc proteins, suggesting a role in Z-disc structure and signal transduction.
Cite This Study
Frey et al. (2002) studied this question. Calsarcin-3 is a novel skeletal muscle-specific protein enriched in fast-twitch fibers that interacts with calcineurin and multiple Z-disc proteins.