Why the study?
Few if any rheological studies validate changes in the physical and mechanical properties of human blood after sustained prophylactic low-dose aspirin administration.
Does daily low-dose aspirin reduce blood viscosity and yield stress in human donors?
Population
Eleven donors
Comparison
Before vs after daily aspirin (81 mg) for 14 consecutive days
Design
Rheological study
Follow-up
14 consecutive days
Key result
Daily administration of 81 mg aspirin for 14 days significantly decreased blood yield stress and infinite shear viscosity (p < 0.05) in healthy adults.
Authors
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Low-dose aspirin decreases blood viscosity and yield stress; leaves open effects on clinical outcomes.
Observational (n=11)
No
Does daily low-dose aspirin reduce blood viscosity and yield stress in human donors?
p-value: p=<0.05
Prophylactic low-dose aspirin reduces blood viscosity and yield stress, providing a rheological mechanism that may contribute to its cardiovascular benefits.
Corrigan et al. (2021) conducted an observational in Healthy adults (n=11). Acetylsalicylic acid (Aspirin) vs. Baseline (pre-administration) was evaluated on Yield stress and infinite shear viscosity (p=<0.05). Daily administration of 81 mg aspirin for 14 days significantly decreased blood yield stress and infinite shear viscosity (p < 0.05) in healthy adults.