Key result
Daily administration of 81 mg aspirin for 14 days significantly decreased blood yield stress and infinite shear viscosity (p < 0.05) in healthy adults.
Why the study?
Few if any rheological studies validate changes in the physical and mechanical properties of human blood after sustained prophylactic low-dose aspirin administration.
Does daily low-dose aspirin reduce blood viscosity and yield stress in human donors?
Observational (n=11)
No
Does daily low-dose aspirin reduce blood viscosity and yield stress in human donors?
Prophylactic low-dose aspirin reduces blood viscosity and yield stress, providing a rheological mechanism that may contribute to its cardiovascular benefits.
Answers are grounded in this paper and cite their sources.
Low-dose aspirin decreases blood viscosity and yield stress; leaves open effects on clinical outcomes.
While the prophylactic use of regular, low dosage, acetylsalicylic acid (aspirin) has been employed due to the inhibitory effect on platelet aggregation, few if any rheological studies validate the change in the physical and mechanical properties of human blood post-aspirin administration. The viscosity and yield stress of blood from eleven donors were assessed at varied shear rates before and after daily aspirin administration (81 mg) for 14 consecutive days. The findings indicate a statistically relevant aggregated decrease with respect to viscosity and yield stress within the study population.
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Corrigan et al. (2021) conducted an observational in Healthy adults (n=11). Acetylsalicylic acid (Aspirin) vs. Baseline (pre-administration) was evaluated on Yield stress and infinite shear viscosity (p=<0.05). Daily administration of 81 mg aspirin for 14 days significantly decreased blood yield stress and infinite shear viscosity (p < 0.05) in healthy adults.
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