Why the study?
Do incremental doses of aspirin affect bleeding time, platelet aggregation, and thromboxane production in patients with cerebrovascular disease?
Population
18 patients with cerebrovascular disease
Comparison
Acetylsalicylic acid in incremental doses of 50… vs Baseline (before administration)
Design
Cohort
Authors
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Low-dose aspirin was associated with near-complete platelet inhibition; hypothesis-generating for dose optimization in cerebrovascular disease.
Do incremental doses of aspirin affect bleeding time, platelet aggregation, and thromboxane production in patients with cerebrovascular disease?
Low-dose aspirin (50-100 mg daily) effectively inhibits platelet function and increases bleeding time in patients with cerebrovascular disease, with higher doses potentially being less effective.
Boss et al. (1985) studied this question.
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