What question did this study set out to answer?

To analyze the potential individual and joint exposure to occupational metals on prostate cancer risk, focusing on tumor aggressiveness and stage.

July 20, 2026Cancer EpidemiologyOpen Access

Occupational exposure to metals and prostate cancer: CAPLIFE study

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Case-control study analyzes risk of prostate cancer with occupational metal exposure, suggesting potential preventive strategies.

To analyze the potential individual and joint exposure to occupational metals on prostate cancer risk, focusing on tumor aggressiveness and stage.
Case-control study with 464 cases and 428 controls
Lifetime occupational exposure estimated using the Spanish job-exposure matrix
Multivariable logistic regression and Quantile g-Computation models assessed individual and joint effects.
No association between individual metal exposure and overall prostate cancer was found
Higher odds for locally advanced or metastatic tumors were observed for chromium, nickel, and iron; specifically, nickel showed aOR evervsnever = 1.99 (95% CI 1.02–3.89)
Joint metal exposure also linked to metastatic tumors with aOR = 1.41 (95% CI 1.04–1.91).

Olmedo‐Requena et al. (2026) studied this question.

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