Key result
Top quartile of day-by-day systolic blood pressure variability during the subacute stage was associated with poor 3-month functional outcome compared to the bottom quartile (OR 1.51; 95% CI 1.09-2.08).
Why the study?
Does high day-by-day blood pressure variability during the subacute stage increase the risk of poor functional outcome in patients with acute ischemic stroke?
Cohort (n=2,566)
Does high day-by-day blood pressure variability during the subacute stage increase the risk of poor functional outcome in patients with acute ischemic stroke?
Odds Ratio: 1.51 (95% CI 1.09–2.08)
Higher day-by-day blood pressure variability during the subacute stage of ischemic stroke is independently associated with worse functional outcomes at 3 months.
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BP variability may predict functional outcome after acute ischemic stroke; hypothesis-generating and requires prospective confirmation before guiding care.
Fukuda et al. (2015) conducted a cohort in Acute ischemic stroke (n=2,566). Top quartile of day-by-day systolic blood pressure variability during the subacute stage vs. Bottom quartile of systolic blood pressure variability was evaluated on Poor functional outcome (modified Rankin Scale scores ≥3 at 3 months) (OR 1.51, 95% CI 1.09-2.08). Top quartile of day-by-day systolic blood pressure variability during the subacute stage was associated with poor 3-month functional outcome compared to the bottom quartile (OR 1.51; 95% CI 1.09-2.08).
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