Key result
Increased day-by-day systolic blood pressure variability within 7 days of acute ischemic stroke onset was independently associated with a higher risk of unfavorable functional outcome at 3 months (OR 1.15).
Why the study?
Previous studies evaluating the association between blood pressure variability in acute ischemic stroke and functional outcome yielded inconsistent results.
Population
367 patients hospitalized for ischemic stroke within 48 hours of onset
Comparison
Day-by-day blood pressure variability (SD and CV) within 7 days of onset
Design
Observational cohort study
Follow-up
3 months
Authors
Loading...
Does not support targeting BP variability after ischemic stroke; leaves open whether reduction improves outcomes.
Observational (n=367)
No
Odds Ratio: 1.15 (95% CI 1.07–1.22)
p-value: p=<0.001
Increased day-by-day blood pressure variability during the acute phase of ischemic stroke is independently associated with a higher risk of unfavorable functional outcome at 3 months.
Yang et al. (2020) conducted an observational in Acute ischemic stroke (n=367). Day-by-day blood pressure variability vs. Lower blood pressure variability was evaluated on Unfavorable functional outcome at 3 months (mRS ≥3) (OR 1.15, 95% CI 1.07-1.22, p=<0.001). Increased day-by-day systolic blood pressure variability within 7 days of acute ischemic stroke onset was independently associated with a higher risk of unfavorable functional outcome at 3 months (OR 1.15).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: