What question did this study set out to answer?

This study aims to explore the differences in glucose uptake and perfusion in adipose tissue between nonobese and obese men during insulin stimulation.

August 1, 2002The Journal of Clinical Endocrinology & MetabolismOpen Access

Glucose Uptake and Perfusion in Subcutaneous and Visceral Adipose Tissue during Insulin Stimulation in Nonobese and Obese Humans

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Authors

KVKirsi A. VirtanenGeneral / Preventive / Lipids PLPeter LönnrothUniversity of Gothenburg RPRiitta ParkkolaUniversity of Turku

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Implication

Randomized trial demonstrates impaired glucose uptake in obese individuals, indicating insulin resistance in adipose tissue.

Key Points

This study aims to explore the differences in glucose uptake and perfusion in adipose tissue between nonobese and obese men during insulin stimulation.
Measured glucose uptake in subcutaneous and visceral adipose tissue using PET imaging and labeled water during insulin stimulation.
Involved 10 nonobese and 10 age-matched obese men, comparing glucose uptake rates and blood flow.
Analyzed fat mass with magnetic resonance images and compared regional glucose uptake rates.
Whole-body glucose uptake rates were lower in obese subjects compared to nonobese (P < 0.01).
Abdominal subcutaneous glucose uptake was 67% lower and visceral glucose uptake was 58% lower in obese than in nonobese individuals.
Insulin resistance was indicated by impaired blood flow and glucose uptake in both sc and visceral adipose tissue in obese subjects (P < 0.05).

Cite This Study

Virtanen et al. (2002) studied this question.

synapsesocial.com/papers/6a5dcc8f646f15684ebc2916 https://doi.org/10.1210/jcem.87.8.8761

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Glucose Uptake and Perfusion in Subcutaneous and Visceral Adipose Tissue during Insulin Stimulation in Nonobese and Obese Humans

Discussion

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Implication

Key Points

Cite This Study

Glucose Uptake and Perfusion in Subcutaneous and Visceral Adipose Tissue during Insulin Stimulation in Nonobese and Obese Humans

Discussion

Member takes

Implication

Key Points

Cite This Study

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