Key result
In conscious rats, GLP-1(7-36) produced tachycardia, increased blood pressure, and regional vascular changes, whereas its cleavage product GLP-1(9-36) was devoid of any cardiovascular actions.
Population
Conscious, chronically instrumented rats
Design
Preclinical
Follow-up
4 hours (infusion duration)
Authors
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Intact GLP-1(7-36) drives rat haemodynamic effects; leaves open translation to human DPP-4 inhibitor responses.
The cardiovascular effects of GLP-1(7-36) in conscious rats are driven by the intact peptide rather than its cleavage product GLP-1(9-36).
Gardiner et al. (2010) studied this question. GLP-1(7-36) amide and GLP-1(9-36) amide was evaluated on Regional haemodynamic effects. In conscious rats, GLP-1(7-36) produced tachycardia, increased blood pressure, and regional vascular changes, whereas its cleavage product GLP-1(9-36) was devoid of any cardiovascular actions.
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