Key result
Myosin VI and dynamin function in parallel pathways to regulate actin dynamics during Drosophila spermatogenesis, with cortactin and arp2/3 complex playing important roles.
Myosin VI and dynamin function in parallel pathways to regulate actin dynamics during membrane remodeling in Drosophila spermatogenesis.
Myosin VI regulates actin dynamics in Drosophila spermatogenesis; leaves open conservation and relevance in mammalian systems.
Myosin VI has been implicated in membrane dynamics in several organisms. The mechanism of its participation in membrane events is not clear. We have used spermatogenesis in Drosophila to investigate myosin VI's in vivo role. We demonstrate that myosin VI colocalizes with and is required for the accumulation of the actin polymerization regulatory proteins, cortactin and arp2/3 complex, on actin structures that mediate membrane remodeling during spermatogenesis. In addition, we show that dynamin localizes to these actin structures and that when dynamin and myosin VI function are both impaired, major defects in actin structures are observed. We conclude that during spermatogenesis myosin VI and dynamin function in parallel pathways that regulate actin dynamics and that cortactin and arp2/3 complex may be important for these functions. Regions of myosin VI accumulation are proposed as sites where actin assembly is coupled to membrane dynamics.
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Rogat et al. (2002) studied Drosophila spermatogenesis. Myosin VI and dynamin impairment was evaluated on Actin dynamics and membrane remodeling. Myosin VI and dynamin function in parallel pathways to regulate actin dynamics during Drosophila spermatogenesis, with cortactin and arp2/3 complex playing important roles.
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